Clinical Studies

Dexcom CGM improves glucose control in Adults (DIaMondD Type 1 Study)

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In this first-of-its kind clinical trial, the benefit of continuous glucose monitoring (CGM) use by patients on multiple daily injections (MDI) insulin therapy was investigated. The evidence was resounding—patients on MDI demonstrated significant improvements across several measures of glycemic control and variability, including:

A1C reduction
Increase of time spent in target range
Reduction of time in hypoglycemia
Reduction of time in hyperglycemia

Objective
Compare ecacy of MDI regimen augmented by CGM vs. self-monitoring of blood glucose (SMBG).
Primary endpoint was A1C reduction in each group.

Research Design/Methods
24-week, randomized controlled trial of 158 adult patients with type 1 diabetes (25 years), split into 2 groups. Patient touchpoints were reflective of common clinical practice (only one additional scheduled follow-up visit for CGM group, one week after CGM was initiated.)
Group 1: MDI+CGM (n=105)
Group 2: MDI+SMBG (n=53)

 

Source: Beck RW, Riddlesworth T, Ruedy K, et al. Effect of continuous glucose monitoring on glycemic control in adults with type 1 diabetes using insulin injections: The diamond randomized clinical trial. JAMA. 2017;317(4):371-378. doi:10.1001/jama.2016.19975.

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