Long-Term Improvements in Glycemic Control with Dexcom CGM Use in Adults with Noninsulin-Treated Type 2 Diabetes

Title: Long-Term Improvements in Glycemic Control with Dexcom CGM Use in Adults with Noninsulin-Treated Type 2 Diabetes

Topics: Long-Term Outcomes, Type 2 Diabetes, Noninsulin-Treated

Research Spotlight: “Long-Term Improvements in Glycemic Control with Dexcom CGM Use in Adults with Noninsulin-Treated Type 2 Diabetes” Layne JE, et al. Diabetes Technology & Therapeutics. 2024.

Background: Continuous glucose monitoring (CGM) has been shown to improve glycemic control in individuals with type 1 diabetes and those with type 2 diabetes (T2D) on intensive insulin therapy. However, there is limited data on the impact of CGM in adults with noninsulin-treated T2D. This study evaluates the long-term effects of CGM use in this population.

Key question: How does long-term use of CGM affect glycemic control in adults with noninsulin-treated T2D?

Main outcomes of the study:

Glycemic Control:
Time in Range (TIR) 70-180 mg/dL: Increased by 17.3% from 41.7% at baseline to 59.0% at 12 months.
Glucose Management Indicator (GMI): Decreased by 0.5% from 8.1% to 7.6%.
Time in Tight Range (TITR) 70-140 mg/dL: Increased significantly, particularly in participants who lowered their high alert threshold.
Time Above Range (TAR) >180 mg/dL: Decreased significantly.
Time Below Range (TBR) <70 mg/dL: Remained low and stable.
CGM Use: High usage was observed, with participants using CGM on 84.7% of days over 12 months.
High Alert Feature: Participants who maintained or customized the high alert setting of 250 mg/dL had greater improvements in TIR and TITR compared to those who disabled the alert.

Key takeaways for healthcare providers:

Long-term use of CGM in adults with noninsulin-treated T2D is associated with significant and sustained improvements in glycemic control.
The high alert feature of CGM can be a valuable tool for enhancing glycemic outcomes, especially when customized to lower thresholds.
Consistent CGM use over 12 months suggests ongoing benefits for managing T2D without insulin.

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Long-Term Improvements in Glycemic Control with Dexcom CGM Use in Adults with Noninsulin-Treated Type 2 Diabetes

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